Found 18 matching trials
Determine the Effects of Gene Differences and Voriconazole on Enzyme CYP2B6 Activity in the Liver in Healthy Volunteers NA The purpose of this study is to see if administration of medicines and gene...
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Indiana University
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Effects of Steady-state Efavirenz 600 mg QD (Sustiva®) on Tipranavir Concentration at Steady-state in Healthy Adult Volunteers PHASE1 Study to investigate the effects of steady-state Efavirenz (600 mg QD) on t...
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Multiple Locations
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Dose Finding Confirmation of Atazanavir With Ritonavir and Efavirenz (ATV/RTV + EFV) in Healthy Subjects PHASE1 The purpose of this study is to assess the exposure of Atazanavir 400 mg wi...
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Local Institution
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Effects of CYP2B6 Genetic Polymorphisms on Efavirenz Pharmacokinetics NA 1. To see how the liver breaks down efavirenz by an enzyme called CYP2B6. I...
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Indiana Clinical Research Center (ICRC)
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CYP2B6 Genetics and Drug Interactions in Healthy Volunteers PHASE4 The CYP2B6 enzyme metabolizes a growing number of clinically important drug...
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Indiana University School of Medicine
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Efficacy Study of Different Laboratory Management Strategies and Drug Regimens in HIV-infected Children in Africa PHASE4 The two original objectives were to determine in HIV-infected children init...
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MRC /UVRI Uganda Research Unit on AIDS
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PK of Efavirenz & Lopinavir Nano-formulations in Healthy Volunteers PHASE1 This study is an open-label, prospective pharmacokinetic study investigatin...
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St Stephen's Centre
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Safety, Tolerability, and Effect of TMC207 and Efavirenz in Healthy Volunteers PHASE1 Common treatments for tuberculosis (TB) can interfere with certain antiretr...
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Multiple Dose Comparison of the Effect of Two Dose Combinations of Tipranavir/Ritonavir (TPV/RTV), on the Pharmacokinetic Characteristics of Efavirenz (Sustiva®) in Healthy Adult Volunteers PHASE1 The objective of this study was to characterize the effects of two dose com...
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Multiple Locations
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Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-lowering Ezetimibe and the Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4, UGT1A1, ABCB1 and ABCC2 PHASE1 The purpose of this study is to evaluate the effects of a chronic co-medica...
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Department of Clinical Pharmacology
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